Skip to main content

Table 1 Differences in clinical presentation and histopathologic features [4]

From: Giant fibroepithelial stromal polyp of the vulva: largest case reported

  Aggressive angiomyxoma Angiomyo-fibroblastoma Cellular angiofibroma Fibroepithelial stromal polyp Superficial angiomyxoma Prepubertal vulval fibroma
Age Reproductive age Reproductive age Reproductive age Reproductive age Reproductive age Prepubertal
Location/Configuration Deep seated, not polypoid Subcutaneous Subcutaneous Usually polypoid, exophytic Superficial subcutaneous, polypoid Submucosal, subcutaneous
Size Variable Usually < 5 cm Usually < 3 cm Variable Usually < 3 cm Usually < 5 cm
Margins Infiltrative Well circumscribed Usually well circumscribed Merges with normal Lobulated, distinct Infiltrative
Cellularity Paucicellular Alternating hypercellular and hypocellular Cellular Variable Hypocellular Hypocellular
Vessels Medium to large, thick-walled, hyalinized Delicate, capillary-sized, numerous Small to medium, thick-walled, hyalinized Variable, usually large, thick-walled central core Delicate, thin-walled, elongated Small to medium-sized vessels
Mitotic Index Rare Usually uncommon Variable, may be brisk Variable Usually uncommon Uncommon
Biomarkers Desmin positive, HGMA2 positive Desmin positive, HGMA2 negative CD 34 positive; Desmin, SMA variable Desmin positive, HGMA2 negative Desmin negative, HGMA2 negative CD 34 positive; desmin, S-100 negative
Clinical course 30% local destructive recurrence Benign Benign Benign, rare recurrence 30% local nondestructive recurrence Benign, may recur