Giant fibroepithelial stromal polyp of the vulva: largest case reported

Table 1 Differences in clinical presentation and histopathologic features [4]

	Aggressive angiomyxoma	Angiomyo-fibroblastoma	Cellular angiofibroma	Fibroepithelial stromal polyp	Superficial angiomyxoma	Prepubertal vulval fibroma
Age	Reproductive age	Reproductive age	Reproductive age	Reproductive age	Reproductive age	Prepubertal
Location/Configuration	Deep seated, not polypoid	Subcutaneous	Subcutaneous	Usually polypoid, exophytic	Superficial subcutaneous, polypoid	Submucosal, subcutaneous
Size	Variable	Usually < 5 cm	Usually < 3 cm	Variable	Usually < 3 cm	Usually < 5 cm
Margins	Infiltrative	Well circumscribed	Usually well circumscribed	Merges with normal	Lobulated, distinct	Infiltrative
Cellularity	Paucicellular	Alternating hypercellular and hypocellular	Cellular	Variable	Hypocellular	Hypocellular
Vessels	Medium to large, thick-walled, hyalinized	Delicate, capillary-sized, numerous	Small to medium, thick-walled, hyalinized	Variable, usually large, thick-walled central core	Delicate, thin-walled, elongated	Small to medium-sized vessels
Mitotic Index	Rare	Usually uncommon	Variable, may be brisk	Variable	Usually uncommon	Uncommon
Biomarkers	Desmin positive, HGMA2 positive	Desmin positive, HGMA2 negative	CD 34 positive; Desmin, SMA variable	Desmin positive, HGMA2 negative	Desmin negative, HGMA2 negative	CD 34 positive; desmin, S-100 negative
Clinical course	30% local destructive recurrence	Benign	Benign	Benign, rare recurrence	30% local nondestructive recurrence	Benign, may recur

ISSN: 1750-1164