Histological evaluation of arteries sealed with the Caiman® 5 instrument. Photomicrographs of H&E stained sections in acute (A, B) and chronic phase (C, D) after sealing with the Caiman® 5 instrument. Serial sections through renal (A, C) and splenic (B, D) arteries. A, B: For both chronic arteries, the black arrow demonstrates the transected end of the artery, which is characterized by coagulative thermal necrosis. The tissue appears fused and sealed. C: The black arrow demarcates the distal end of the transected segment surrounded by a cap of fibroplasia. There is an occlusive, organized luminal thrombus, and the distal end of the artery is suffused with hemorrhage; a modest amount of fibrous fibers dissects into the surrounding fat. D: The black arrow indicates the occlusive organized luminal thrombus. The transected end of the artery is surrounded by a fibrous cap.