Table 1 Summary of study characteristics
Study, Year | Study design | End point | Definition of Colonisation | Definition of CRBSI |
|---|---|---|---|---|
Bijma [7], 1999 | Prospective longitudinal cohort study | Impact of intervention plan on CVC colonisation and infection incidence | Growth of >15 cfu from the removed tip | Clinical signs of BSI in the absence of another focus of infection + both peripheral blood culture and catheter tip culture test positive for same organism |
Dimick [8], 2001 | Prospective cohort study | Estimated increase in resource use associated with CRBSI of critically ill surgical patients after adjusting for severity of illness. | Growth of >15 cfu from the removed tip | Both peripheral blood culture and catheter tip culture test positive for same organism within 48 hours of each other |
Dimick [9], 2003 | Prospective cohort study | Multipurpose CVC vs TPN CVC; risk factors, incidence and pathogens of CRBSI | Growth of >15 cfu from the removed tip | Both peripheral blood culture and catheter tip culture test positive for same organism within 48 hours of each other |
Sandoe [10], 2003 | Prospective cohort study | Impact of extended routine perioperative antibiotic prophylaxis on incidence of CVC colonisation and infection | Growth of >15 cfu from the removed tip | Positive same-organism peripheral blood culture and catheter tip culture when catheter in situ |
Pawar [11], 2004 | Prospective cohort study | Incidence, risk factors, outcome, and pathogens of CVC-BSI | Growth of <15 cfu from the removed tip | Clinical signs of BSI and both peripheral blood culture and catheter tip culture test positive for same organism OR resolution of fever after the removal of a CVC suspected of infection. |
Le Guillou [12], 2011 | Retrospective cohort study | Proportion of surgical-site infections (SSIs) with possible attribution to CRBSI, risk factors associated with SSI after CRBSI. | Growth of >103 cfu/mL, and without clinical evidence of infection | BSI occurring 48 hours before/after catheter removal and positive culture with the same micro- organism of either (i) quantitative CVC culture >103 cfu/mL; (ii) positive culture from pus from insertion site; (iii) quantitative blood culture ratio CVC blood sample: peripheral blood sample >5; or (iv) differential time to positivity of blood cultures: CVC blood sample culture positive >2 hours before peripheral blood culture (blood samples drawn at the same time). |
Gunst [13], 2011 | Retrospective cohort study | PICC VS CVC risk factors and incidence of CRBSI | Growth of >15 cfu from the removed tip | Both peripheral blood culture and catheter tip culture test positive for same organism |