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Table 1 Summary of study characteristics

From: Central and peripheral venous lines-associated blood stream infections in the critically ill surgical patients

Study, Year Study design End point Definition of Colonisation Definition of CRBSI
Bijma [7], 1999 Prospective longitudinal cohort study Impact of intervention plan on CVC colonisation and infection incidence Growth of >15 cfu from the removed tip Clinical signs of BSI in the absence of another focus of infection + both peripheral blood culture and catheter tip culture test positive for same organism
Dimick [8], 2001 Prospective cohort study Estimated increase in resource use associated with CRBSI of critically ill surgical patients after adjusting for severity of illness. Growth of >15 cfu from the removed tip Both peripheral blood culture and catheter tip culture test positive for same organism within 48 hours of each other
Dimick [9], 2003 Prospective cohort study Multipurpose CVC vs TPN CVC; risk factors, incidence and pathogens of CRBSI Growth of >15 cfu from the removed tip Both peripheral blood culture and catheter tip culture test positive for same organism within 48 hours of each other
Sandoe [10], 2003 Prospective cohort study Impact of extended routine perioperative antibiotic prophylaxis on incidence of CVC colonisation and infection Growth of >15 cfu from the removed tip Positive same-organism peripheral blood culture and catheter tip culture when catheter in situ
Pawar [11], 2004 Prospective cohort study Incidence, risk factors, outcome, and pathogens of CVC-BSI Growth of <15 cfu from the removed tip Clinical signs of BSI and both peripheral blood culture and catheter tip culture test positive for same organism OR resolution of fever after the removal of a CVC suspected of infection.
Le Guillou [12], 2011 Retrospective cohort study Proportion of surgical-site infections (SSIs) with possible attribution to CRBSI, risk factors associated with SSI after CRBSI. Growth of >103 cfu/mL, and without clinical evidence of infection BSI occurring 48 hours before/after catheter removal and positive culture with the same micro- organism of either (i) quantitative CVC culture >103 cfu/mL; (ii) positive culture from pus from insertion site; (iii) quantitative blood culture ratio CVC blood sample: peripheral blood sample >5; or (iv) differential time to positivity of blood cultures: CVC blood sample culture positive >2 hours before peripheral blood culture (blood samples drawn at the same time).
Gunst [13], 2011 Retrospective cohort study PICC VS CVC risk factors and incidence of CRBSI Growth of >15 cfu from the removed tip Both peripheral blood culture and catheter tip culture test positive for same organism
  1. Abbreviations: CVC: Central venous catheter; PICC: Peripherally inserted central catheter; cfu: Colony forming units; TPN: Total parenteral nutrition; BSI: Bloodstream infection.