Kaplan-Meier estimates for the probability of bleeding after treatment with different concentrations of rThrombin or placebo. TTH was measured in the rabbit AV shunt model of anastomotic bleeding after treatment with heparin + clopidogrel. PTFE graft segments were punctured, and AGS containing a standardized volume of 1000 IU/mL or 125 IU/mL rThrombin or placebo was applied to the bleeding surface. The TTH observation period extended from 60 seconds to 300 seconds. 1000 IU/mL rThrombin: N = 14 grafts. 125 IU/mL rThrombin: N = 14 grafts. Placebo: N = 10 grafts.